and executing a variety of cell-based immunological assays and in vivo experiments using tumor and autoimmune mouse models. This role will employ industry-leading technologies to address pertinent questions in cancer immunology and autoimmunity. Please see our relevant published work: Waite JC et al.
Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed. aba2325Skokos D et al. Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed. aaw7888As a Principal Scientist in the Cancer Immunology team, a typical day might include the following: Developing, optimizing, and performing various immunoassays to evaluate therapeutic candidates' impact on immune cell function and phenotype, including advanced
techniques such as multicolor flow cytometry and fluorescence microscopy. Independently planning and executing in vivo studies using tumor and autoimmune mouse models.
These will include treatments with injections through various routes (IP, IV, SC), blood and tissue collection for downstream analysis of immune responses. Analyzing data using biological and statistical software such as OMIQ, Prism, Excel, etc. Collaborating with cross-functional scientists to drive target validation and therapeutic antibody development. Delivering impactful presentations to colleagues across our business, including senior leadership. Writing protocols and study reports, maintaining accurate electronic
records. Routinely reviewing relevant literature, attending scientific meetings, and improving expertise in the field of Immunology and Immuno-Oncology.
Training and management of research associates as needed. This role might be for you if you: Get excited about developing immunotherapies that promote a tumor-specific and durable immune response to eradicate cancer for patients. Have a passion for innovation and desire to lead new scientific directions. Are a team player with a collaborative spirit. Possess excellent communication, organization, and time management skills. Independently design and execute experiments, analyze data, and interpret results. Are confident with multitasking and managing multiple projects simultaneously.
This role requires a Ph. D. in immunology, immuno-oncology, or a related field, 5+ years of relevant industry and/or academic related experience, and a strong record of innovation and publications. Proven expertise in T cell biology with experience using mouse tumor and autoimmune models, including high dimensional immunophenotyping, is required. Proficiency with fluorescence microscopy and advanced imaging techniques is a plus. Does this sound like you? Apply now to take your first steps toward living the Regeneron Way!
We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U.
S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $121,200.00 - $197,800.00
You will have the opportunity to establish manufacturing platforms and guide product development through all stages of development to ensure project advancement. This role is based in Florham Park, NJ In this role a typical day may include: Independently design studies aimed at optimizing and improving expansion and manufacturability of candidate products based on the biology and the target.
Design and execute experiments using approaches such as DOE or QBD, maintain detailed records of results, and present results to multi-disciplinary teams and leadership. Apply DOE/DQB for process characterization, establish process parameters, and contribute to CMC sections of regulatory filings.
Develop cell isolation, enrichment, separation and formulation protocols and technologies/ platforms to support product development. Develop processes that integrate innovative approaches to increase the functional capability and yield of gd T cells.
Relying on an in-depth CAR-T background, perform statistical analyses using product attribute data to assist, guide, and execute comparability studies. Develop and oversee tech transfer of protocols to CDMO. Collaborate with SME(s) at CDMOs to deliver timely and accurate technical solutions to resolve investigations and improve manufacturing performance and reliability. Present experimental outcomes, process analytics, and data trends to
larger cross functional groups and leadership. T his role may be for you if you: Enjoy the challenge of developing and improving processes for CAR-T manufacture.
Desire an opportunity to make key and highly visible contributions. Have a sound understanding in various approaches for CAR-T manufacture. Enjoy working in a matrix environment and guiding collaborations. To be considered for this role, you must have a Ph. D. + 6 years in immunology or bioengineering discipline with relevant industry experience, including cell therapy process development. We need someone with extensive hands-on experience in cell culture (primary cells and cell lines), aseptic culture, as well as genetic modification of cells using transduction and/or transfection.
Experience with gamma delta and other T cell lineages is needed. Experience in establishing cell therapy manufacturing processes and improving scalable upstream processes in the PD setting is required. Experience using wave rocker systems, benchtop bioreactors, Sepax, LOVO, and closed harvest systems will be needed. Familiarity with flow cytometry assays and other cell-based characterization assays (i. e. cytokine release and cytolytic assays) is a plus. Proven experience in the transfer of technologies/processes.
Demonstrated capability to conduct/document complex manufacturing processes, familiarity with FDA guidance's, and an understanding of GMP GDP/quality is preferred. Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process.
Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $121,200.00 - $197,800.00
of T cell biology, with a main emphasis on harnessing immunoregulatory mechanisms for reestablishing immune and tissue homeostasis under inflammatory conditions. The candidate will be expected to work independently and collaboratively on pipeline projects and will be responsible for advancing exciting and novel research stage programs into early clinical development, providing both scientific and technical expertise and generating solid proof of concept data.
No prior industry experience is required, but an open and curious scientific mind is essential. Excellent communication skills, will facilitate fruitful and open collaborations with other labs in immunology, regenerative medicine,
human genetics, biomarker discovery and early clinical development. Time and space will be provided to drive both pipeline research and also explore new biologies and pathways for new target discovery.
Using state of the art techniques and technologies, the candidate will have the capacity to develop in vitro and in vivo skills to test the involvement of novel pathways and molecules in the pathogenesis of inflammatory diseases and to identify the mechanism of action (MOA) of new targets. Strong candidates for this position will meet most of the following requirements: Ph D degree and post-doctoral experience in immunology, molecular biology, biochemistry or related field. A strong background
in T cell immunology is desirable. Demonstrated record of professional achievement in the form of high-quality publications.
Extensive hands-on experience in cellular and molecular immunology techniques including primary cell isolation from tissues, in vitro immunological assays, multi-dimensional flow cytometry and in vivo animal models. Experience with state-of-the-art precision genome editing technologies and their application for cell engineering is of particular interest. Experience with analysis of data from genomic sequencing, sc RNA-seq, TCR-seq, CITE-seq or spatial transcriptomics is a plus. Independently designing, executing and interpreting experiments.
Have excellent communication skills and willing to work in a collaborative environment and core lab. Can present research at intra- and inter-departmental meetings. Relocation benefits are available for this job postingThe expected salary range for this position based on the primary location of California is $98,200 and $182,400 of hiring range. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits#LI-JD1#researcherjob Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
evaluating therapeutic candidates in these models. A strong emphasis on creativity and ingenuity to challenge existing dogmas and investigate unsolved problems in genetics medicines will be required. Your immunology expertise combined with Regeneron's technology platforms, including viral and non-viral gene therapy, CRISPR-mediated gene editing, Veloci Gene transgenic mouse models, and the extensive catalog of fully human therapeutic antibodies, will be used to make immediate contributions to the field of immunology of genetics medicines.
As a Sr. Scientist, a typical day may include the following: Design, perform, analyze, and troubleshoot in vitro and in vivo mouse experiments to investigate
and validate therapeutic targets Design, coordinate, analyze large animal model immunology-focused experiments with external vendors to inform clinical program development Design and run animal/human ELISpots, immunophenotyping, and other relevant T cell assays Collaborate with team members and provide immunological wisdom Provide occasional experimental support for existing late-stage preclinical assets in the pipeline Participate and present in departmental meetings and external conferences This role may be for you if: You enjoy working in an innovative and cross-functional team.
You have a passion for championing new immunomodulatory therapeutics. You have strong organizational, time-management,
and communication skills. You can effectively and rationally balance and prioritize multiple projects.
This role requires a Ph. D. in immunology or a related field or a B. S. /M. S. with 10 years in an immunology-focused role. A strong background in in vivo T cell biology with experience in both humans and mouse models. Experience in developing and running immune functional assays of primary human blood/tissue products is highly desired. Familiarity with the unique challenges of immune responses in gene therapies and gene editing are a plus. #LI-onsite#RGMDoes this sound like you? Apply now to take your first steps toward living the Regeneron Way!
We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U.
S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $103,600.00 - $169,000.00
The candidate will also provide molecular biology support for the group including cloning and generation of expression constructs. KEY RESPONSIBILITIES: Perform purification of recombinant proteins using chromatographic methods. QC protein reagents for different applications.
Characterize proteins via SDS-PAGE, western blot, and other biochemical and biophysical methods. Perform cloning, mutagenesis, and generate expression vectors. Ensure that experiments are planned and coordinated cross-functionally, as well as executed effectively. Handle or communicate issues in a timely manner. Provide scientific insight to overcome challenges (e. g. protein solubility, purity, heterogeneity, yield).
Continuously drive for improved process performance. Generate associated technical reports and documents. Able to work independently as well as within a team environment.
Be accountable for technical performance and help drive results of the team. QUALIFICATIONS: BS or MS in molecular biology, biochemistry, biotechnology, or other relevant biological sciences. BS with typically 3 - 7 years or MS with typically 0 - 5 years of experience. Proven experience in protein expression and purification. Familiarity with the AKTA purification system is preferred but not required. Prior experience in supporting protein structural biology and biophysical characterizations of proteins is beneficial.
Experience in cloning and related molecular biology methods.
Good problem-solving and communication skills. Good record keeping and able to efficiently manage several projects simultaneously in a dynamic environment. Position will be filled at level commensurate with extent of education, experience, and accomplishment. Abb Vie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is Abb Vie's policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, interaction (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, interactionual orientation, marital status, status as a protected veteran, or any other legally protected group status.
of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Join Takeda as a Biomarker Senior Scientist where you will work in the Gastroenterology Drug Discovery Unit (GI DDU) and lead efforts focused on the discovery and validation of novel biomarkers for certain drug targets in liver fibrosis and other chronic liver diseases. You will have a strong scientific background
in liver fibrosis and/or metabolic diseases with experience in biomarker identification and development. You will also be responsible for biomarker discovery and validation efforts for novel targets and drug candidates and independently design and implement extensive biomarker research strategies to support multiple projects in collaboration with internal research teams, external partners and/or CROs.
As part of the Liver Disease Research team, you will report to the Associate Scientific Director and work with the GI DDU. How you will contribute: Develop and implement new biomarker concepts for the treatment of liver fibrosis and other chronic liver diseases. This includes biomarker identification,
development and validation etc. Develop and oversee novel scientific biomarker projects in collaboration with internal and external partners.
Establishes project direction integrating science, key technical knowledge, and program objectives. Manages relevant biomarker strategy for target and drug candidate discovery, validation and mechanism of action studies using contemporary in vitro/ in vivo methods and tools. Participate on cross-functional teams and provide technical leadership in area of expertise. Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas.
Prepare technical reports, summaries and quantitative analyses in written and/or oral form. Communicate with colleagues effectively. Present data to other scientific staff or cross-functional project team; may present data/posters to external research or scientific community and publish research results as appropriate. Act as a biomarker lead to be involved in different stages of portfolio projects to provide input and contribute to Go or No Go decisions for various milestones. Performs as a role model supporting Takeda culture and follow policies.
Minimum Requirements/Qualifications: Ph. D. degree in biology, cardio/metabolic diseases, or immunology or molecular pharmacology with 3+ years relevant post-doc experience or equivalent drug discovery experience in a biotech or medical industry research setting with an additional 2+ years of experience, or MS with 9+ years of experience, or BS with 11+ years' experience. Previous experience in relevant protein and RNA-based assays as well as use of multiomic approaches for biomarker discovery, validation or development is required. Previous experience in NASH/chronic liver disease or fibrotic diseases or understanding of liver disease pathogenesis and pre-clinical therapeutic mechanisms of action research.
Demonstrated ability to independently design and solve scientific problems using multiple, state-of-the-art technologies, experimental methods, and approaches is required. Demonstrated ability to generate and implement a biomarker discovery strategy for a program in an industry setting is required. Previous experience and lab skills to address various types of biomarkers, modalities, and matrices, across animal models and human samples is preferred. Previous experience with translational biomarker research and working experience with clinical samples is preferred.
Previous experience of using Omics platforms and collaboration with computational biologists. Good understanding of current liver fibrosis biomarkers is a plus. Good project management skills with a good understanding in various scientific disciplines in drug discovery (Pharmacology, Toxicology, DMPK, etc. ) is a plus. Demonstrated track record by publications in scientific journals. Good communication skills (oral, written, and presentation) and a good team player. What Takeda can offer you: Comprehensive Healthcare: Medical, Dental, and Vision Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs and company match of charitable contributions Family Planning Support Flexible Ways of Working Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty medicals and best in class patient support programs.
Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work. Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Base Salary Range: $130,200.00 to $186,000.00, based on candidate professional experience level. Employees may also be eligible for Short-term and Long-Term Incentive benefits as well.
Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off. The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply. #LI-SB1#LI-Onsite EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations San Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type Full time
digital pathology research for programs in clinical development. For this position, we are seeking a demonstrated scientific leader with a consistent and outstanding record of creativity and performance in digital pathology or spatial 'omics for cancer biology R&D, evidenced by peer reviewed publications in top tier journals, patent applications, and/or publicly available code repository.
As a Senior Principal Scientist, you are expected to: • Lead the application and development of digital pathology methods to extract disease biology insights and support innovative clinical development programs. • Actively and collaboratively promote scientific and technical innovation with other members
of the department, including subject matter experts in disease biology, companion diagnostics, and data science. • Direct and support publications in high quality scientific, technical, or medical journals.
• Represent the department and translational teams externally through interactions with computational collaborators. • Interact with key partners and investigators and effectively manage internal and external scientific collaborations. • Participate and thrive in an interactive, collaborative, and team-oriented culture. Who You Are: • Ph D degree in a relevant field (e. puter science, computational biology, bioinformatics, molecular biology, cancer biology). • Minimum of 7 years post-Ph
D experience, with demonstrated scientific leadership in digital pathology for oncology in academia and/or industry.
• Fluency with Python and data analysis using modern frameworks (e. g. R, Num Py). • Experience with image analysis, machine learning, and deep learning frameworks (e. g. Pytorch, Tensor Flow-Keras). • Enthusiasm for understanding and discerning the biological context of disease. • Excellent communication and collaboration skills. The expected salary range for this position based on the primary location of South San Francisco, CA is $169,800-315,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.
A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits#g CSGenentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
oncology digital pathology research for programs in clinical development. For this position, we are seeking a demonstrated scientific leader with a consistent and outstanding record of creativity and performance in digital pathology or spatial 'omics for cancer biology R&D, evidenced by peer reviewed publications in top tier journals, patent applications, and/or publicly available code repository.
As a Senior Principal Scientist, you are expected to: • Lead the application and development of digital pathology methods to extract disease biology insights and support innovative clinical development programs. • Actively and collaboratively promote scientific and technical innovation with
other members of the department, including subject matter experts in disease biology, companion diagnostics, and data science. • Direct and support publications in high quality scientific, technical, or medical journals.
• Represent the department and translational teams externally through interactions with computational collaborators. • Interact with key partners and investigators and effectively manage internal and external scientific collaborations. • Participate and thrive in an interactive, collaborative, and team-oriented culture. Who You Are: • Ph D degree in a relevant field (e. puter science, computational biology, bioinformatics, molecular biology, cancer biology). • Minimum
of 7 years post-Ph D experience, with demonstrated scientific leadership in digital pathology for oncology in academia and/or industry.
• Fluency with Python and data analysis using modern frameworks (e. g. R, Num Py). • Experience with image analysis, machine learning, and deep learning frameworks (e. g. Pytorch, Tensor Flow-Keras). • Enthusiasm for understanding and discerning the biological context of disease. • Excellent communication and collaboration skills. The expected salary range for this position based on the primary location of South San Francisco, CA is $169,800-315,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.
A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits#g CS Who we are A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
in cutting edge immunological research as part of our discovery efforts and to contribute to human health at every stage of drug discovery and development. You will have the opportunity to support a broad pipeline in autoimmune and inflammatory diseases by executing in vivo experiments as well as in vitro assays.
As a scientist, your typical day might include: Designing, planning, and/or performing in vivo studies using mouse models of autoimmunity and other inflammatory diseases including tumor models. Processing of organs for immune cell isolation and analysis. Maintaining, expanding, and/or modulating cells and evaluating using in vitro assays. Analysis of data using biological and
statistical software such as flowjo, excel, prism. Close collaborative interactions with teams across the organization. Documentation of experimental procedures and results.
This role may be for you if you: Prefer working in an innovative and team-driven environment. Possess excellent organizational skills. Communicate openly and frequently with manager and team members. Exhibit strong communication and critical thinking skills. Enjoy creativity, independent thinking, and finding solutions to seemingly " impossible" problems. Seek an opportunity to constantly grow and learn about new areas through collaborative projects across multiple teams. To be considered for this role,
you must have a Ph D with 5 years of relevant experience. Training in the proper handling and care of mice and the collection and processing of blood and tissue samples is strongly preferred.
Experience in techniques including tissue culture (maintenance of transformed and primary cells), cell-based assays, and flow cytometry is highly desirable. You will have the opportunity to engage with multiple projects beyond autoimmunity in a fast-paced and data-driven environment with both basic research and pipeline implications. #LI-onsite Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U.
S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $103,600.00 - $169,000.00
therapeutic strategies and approaches. The qualified candidate will also be responsible for recommending, adapting and developing analytical methods for protein characterization. You must have in-depth knowledge of macromolecular physical chemistry especially solution interactions and hands-on experience in protein characterization using a variety of analytical tools.
The candidate is encouraged to be proficient with experimental design and an effective communicator of ideas, project goals and results to team members within the group and with colleagues in collaborating departments. You will proactively identify issues and develop solutions in a collaborative multidisciplinary environment
is crucial. The successful candidate is expected to also lead and build an effective team of scientists and be responsible their career development. A day as a Sr.
Principal Scientist looks like: Participates in and leads all aspects of protein or new modality characterization to provide molecular profiles and developability backssments of therapeutic assets, that support the pipeline, in a timely manner and aligned with partner functions. Reviews the literature and, drawing on in-depth knowledge and experience, designs experiments that solve biophysical problems for key collaborators. Has fundamental knowledge of assay qualification and statistical experimental design and decision making.
Supervises and supports junior scientists with critical data review as well as career development.
Builds an effective molecular characterization team. Ability and enthusiasm for independently learning new methods and softwares. Is a go-to resource for explaining and solving biophysical problems. Provides biophysical support and analytical development for both upstream and downstream functional groups; helps solve problems in real-time. Practical knowledge of downstream purification and formulation development of biologics and drug product profiles aligned with therapeutic strategies. Has generally good technical writing skills. Documents experiments, results and findings in electronic laboratory notebook; presents work at group and department meetings; contributes to drafting of analytical characterization reports, regulatory submission sections, and peer-reviewed articles for publication.
May serve as a team representative in drug candidate-specific development team meetings, and share knowledge and expertise of biophysical chemistry at cross-function team meetings. -Understands how to strategically position internal characterization efforts and collaborations within Protein Biochemistry and with Regeneron partner groups for optimum visibility.
This role may be for you if you have: Have excellent written and verbal communication skills. The successful candidate must be able to prepare slides, author reports and manuscripts for internal and external presentations, and peer-reviewed publications. The desire and ability to work in a team environment. A passion for science and innovation with a strong commitment to continual improvement and making significant contributions. Experience demonstrating broad, in-depth knowledge of macromolecular solution chemistry and biophysics and how this applies to proteins, polymers, viruses, particles and nucleic acids.
Experience designing and solve analytical methods and demonstrate the ability to plan, design, implement laboratory experimentation to advance projects. Experience with statistical and experimental design, molecular modeling, graphing and mathematical analysis softwares is a plus. In order to be considered qualified for this role, you must have a Ph D in medical sciences, biophysics, biochemistry, chemical engineering or equivalent with at least 5 years post-doctoral training combined with industry experience in characterization of therapeutic protein candidates (and/or AAVs, oligonuceleotides).
Knowledge of and demonstrated expertise operating light scattering, liquid chromatography, and capillary electrophoresis instrumentation is essential. Experience in spectroscopic (e. g. CD, fluorescence, and/or FTIR) principles and applications for analysis of proteins, size-based (AUC, LC, MALS) and charge-based (e. g. ic IEF, IEX) separation techniques is important. In-silico modeling skills are a bonus. Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location.
Salary Range (annually) $141,800.00 - $231,400.00
Lewy Body, Alzheimer's, Fronto-Temporal Dementia, Motor Neuron Disorders, Autism Spectrum Disorder, Schizophrenia, Depression, and Pain. In this role, you will support target research and validation, development of new technologies, creation of disease models and preclinical development of novel therapeutics to treat Parkinson's disease and other neurodegenerative diseases.
As an Associate Scientist, a typical day might include: Conducting experiments to study and target the pathophysiological mechanisms of Parkinson's disease and other neurodegenerative disorders. Testing novel therapeutic strategies in animal models. Planning, initiating, and completing in vivo experiments: Mouse handling
and monitoring, behavioral assays, anesthesia, dosing (IV, IP, SQ, RO), surgeries (including stereotaxic surgeries), dissections and sample collections (brain, peripheral tissues and biofluids).
Evaluating misfolded protein uptake, aggregation and spread using molecular biology techniques, biochemistry and immunohistochemistry Surveying literature to expand knowledge, optimize and develop new assays and bring new ideas to the table. Performing sophisticated data analysis as well as troubleshooting with minimal direction. Becoming an active participant of teamwork within the neuroscience department and collaborations with cross-functional groups. Keeping well-organized records of experiments.
Communicating and reporting findings at group meetings.
This role may be for you if you: Enjoy working in a highly collaborative and fast-paced environment. Possess strong organizational and time management skills to advance projects in parallel optimally. Exhibit excellent communication and presentation skills. Demonstrate scientific rigor and pay attention to details. To be considered for this role, you must have at minimum of Bachelor of Science + 2 years (minimum) experience or a Master of Science with experience in Neuroscience, Biology, or a related field. You should also have hands-on experience in a laboratory research setting; Industry or academic experience with in vivo models of neurodegenerative diseases is highly desirable, experience with animal handling is required; Experience with molecular, cellular, biochemical, behavioral methods for the study of the nervous system is preferred ; Excellent verbal and communication skills; Ability to work both independently and in a team environment are required.
Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $66,400.00 - $103,800.00
and biological scientists to perform translational oncology research around multimodal translational data sets for programs in clinical development. For this position, we are seeking a demonstrated scientific leader with a consistent and outstanding record of creativity and performance in multimodal data integration and analysis for cancer biology R&D, evidenced by peer reviewed publications in top tier journals, patent applications, and/or publicly available code repository.
As a Principal AI Scientist, you are expected to: Lead advanced machine learning and analytical method application to extract disease biology insights and support innovative clinical development programs and publications
on multimodal translational data sets that include single cell and spatial 'omics, RNAseq, ct DNA, digital pathology, and clinical data. Actively and collaboratively promote scientific and technical innovation with other members of the Department.
Direct and support publications in high quality scientific, technical or medical journals. Represent the department and translational teams externally through interactions with our key computational collaborators. Interact with key partners and investigators and effectively manage internal and external scientific collaborations. Participate and thrive in an interactive, collaborative, and team-oriented culture. Who You Are Ph D degree in a relevant
field (e. puter science, computational biology, bioinformatics, molecular biology, cancer biology, genomics).
Minimum of 3 years post-Ph D experience, with demonstrated scientific leadership in integrating, analyzing, and interpreting multimodal biological data in an academic and/or industry setting. Fluency with Python and data analysis using modern frameworks for deep learning (e. g. Pytorch, Tensor Flow-Keras). Experience with RNAseq data, systems biology tools, and pathway analysis. Excellent communication and collaboration skills. Experience with image analysis methods, particularly around spatial biology, is desirable. The expected salary range for this position based on the primary location of South San Francisco, CA is $165,600- $307,500.
Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits#g CS Who we are A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases.
Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve.
We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
For more information about equal employment opportunity, visit our Genentech Careers Homepage. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers. /working-with-us. The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at
the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies and transforming response and durability rates for cancer patients.
Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies. We are seeking a highly motivated and experienced individual with deep translational expertise to join the Translational Development team within the Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol Myers Squibb in Redwood City, CA. Position
Responsibilities: In this role as Senior Principal Scientist, Translational Biomarker Lead, within the TME TRC Translational Development team, the ideal candidate: Designs, develops, establishes, and executes well-crafted asset-level oncology translational plans and biomarker strategies for First In Human through Proof of Concept studies within the TME TRC, focused on mechanism of action, target engagement and pharmacodynamic biomarker assays and potential clinical trial patient stratification and selection assays.
Accountable for creation and analysis of the assay development and clinical sample analysis plans, budgets, and data, such as generating qualification/validation plans and study reports, developing SOPs, reviewing qualification/validation reports, and contributing to, and reviewing all, pertinent documentation for assigned programs in collaboration with relevant internal subject matter experts Effectively partners within a highly matrixed organization within the Translational Development group, within the TME TRC, with oncology program colleagues & with external partners to deliver high-quality biomarker data and drive the advancement of therapeutic candidates.
Integrates discovery, translational research and other relevant assay information and data, along with logistics and quality considerations, to inform highly complex ideas, activities, and projects.
Accountable for providing scientific input and biomarker expertise across all aspects of early development plans and collaborations (such clinical protocols, sample collection tables, sample collection instructions and logistics, scopes of work, data transfer agreements, validation reports, study reports, central lab logistics, posters, publications, investigator brochures, INDs, regulatory documents, etc. ) Progresses translational plans into implementation and execution via leading Translational Subteams, monitoring and tracking assay and analysis status and deliverables, via collaboration with internal technical assay execution and/or execution with external contract research organizations (CROs) and/or specialty testing laboratories Supports due diligence, collaboration and asset integration activities as needed Proactively provides insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles, as well as input around tumor types and potential impact of biomarkers on internal decision making.
Provides oversight to progress validated biomarkers into development of diagnostic assays, as needed Participates in strategic review and input to presentations, publications and internal/ external communications along with accountable program leadership and in governance forums Develops solutions and courses of action for senior staff, including identification of risks and risk mitigations Shares expertise, experience, lessons learned and knowledge with translational and other relevant scientific experts and colleagues across the organization Experience = Basic Qualifications: Bachelor's Degree 10+ years of academic and / or industry experience Or Master's Degree 8+ years of academic and / or industry experience Or Ph.
D. or equivalent advanced degree in the Life Sciences 6+ years of academic and / or industry experience 2+ years of leadership experience Preferred Qualifications: Ph D or MD/Ph D with 7+ years of relevant industry experience in the drug development process, preferred within oncology translational biomarker roles and with solid tumor and immune oncology experience Experience from FIH through at least phase 2 trials, including directly contributing to clinical translational and biomarker components of study protocols, laboratory manuals, investigator brochures, regulatory documents, and INDs Experience interfacing with clinical teams and presenting at strategic meetings, and demonstrated ability to lead and influence others in a highly matrixed work environment Working knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, etc Demonstrated scientific acumen and mechanistic understanding of disease biology and experience in oncology and immuno-oncology drug development (small molecule and biologics) Excellent communication skills and comfortable working in a fast-paced environment where speed is paramount Experience in the design, execution and generation of clinical trial translational biomarker assays and data in oncology across multiple technologies and sample types (e.
g. genomics, immunohistochemistry, flow cytometry, immunoassay and other technologies) in various stages of clinical development Ability to effectively collaborate with internal and external partners (e. g. CROs, specialty labs, etc. ) Comfortable working in a fast-paced environment The starting compensation for this job is a range from $159,000.00 - $185,000.00, plus incentive cash and stock opportunities (based on eligibility).
The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, shop, dental and vision care.
Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program. BMSONCRDBMSDDTMRCA#LI-Hybrid If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as " Transforming patients' lives through science™ " every BMS employee plays an integral role in work that goes far beyond ordinary.
Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to xyz X@.
Visit careers. /eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role. R-169504 Scientist - Oncology (In Vivo Pharmacology) Live What you will do Let's do this.
Let's change the world. In this vital role you will be part of a fast-paced, integrated and interactive research group exploring therapeutics for Oncology, Inflammation and Cancer Immunotherapy programs. The Scientist will be responsible for designing, generating and communicating pharmacology and preclinical data to support the progression of oncology and inflammation research teams. Designing,
conducting, analyzing and reporting in vivo and in vitro studies. In vivo work will include handling techniques, such as, tumor inoculation and measurement, oral, sc and iv dosing, blood, tissue collection and model development In vitro work includes a range of cellular assays including flow cytometry and molecular biology techniques to help interpret in vivo observations Operation and maintenance of laboratory equipment, accurate, timely record keeping and data analysis Participation in and presentation at cross-departmental teams and meetings Win What we expect of you We are all different, yet we all use our unique contributions to serve patients.
The dynamic professional we seek is
a scientist with these qualifications. Basic Qualifications: Doctorate degree ORMaster's degree and 4 years of Scientific experience ORBachelor's degree and 6 years of Scientific experience Preferred Qualifications: Doctoral Degree Master's Degree and 5+ years of scientific experience in an industry setting Hands on experience administering drugs through various routes Hands on experience with molecular and cellular biological techniques Hands on experience with flow cytometry and multi-parametric analysis (5+ colors) Research experience with preclinical models of cancer, inflammation and cancer immunotherapy Previous drug discovery experience Computer literacy, especially proficiency with Graphpad Prism, Excel, Powerpoint and Word Excellent organizational and communication skills, along with the ability to work in a flexible team oriented environment Attention to detail, translating into high quality results The ability to work independently on research goals and to direct the research and day to day responsibilities of others Pro-active, enthusiastic, show a desire to learn and be a part of a busy, highly productive team Thrive What you can expect of us As we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being.
Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including: Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans and bi-annual company-wide shutdowns Flexible work models, including remote work arrangements, where possible Apply now for a career that defies imagination Objects in your future are closer than they appear.
Join us. careers. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, interaction, interactionual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Please contact us to request accommodation. Salary Range 115,550.00 USD - 129,548.00 USD
Science Jobs refers to a category of employment that specializes in the field of science, encompassing a diverse range of professions including researchers, laboratory technicians, science educators, and many others engaged in scientific disciplines. These jobs are characterized by their focus on inquiry, exploration, and the application of scientific methods to understand the natural world. They often require a strong educational background in science, critical thinking, problem-solving skills, and sometimes, experience with specialized equipment or software. In today's world, Science Jobs are crucial for innovation, technological advancement, and addressing complex challenges in healthcare, environment, and industry.
