Senior Scientist, In vivo Pharmacology: Immuno-Oncology Early Discovery | Waltham, MA

our team in Waltham, MA USA. As a Senior Scientist in the IO Discovery group, you will be a key member of a team focused on delivering all aspects of in vivo pharmacology support. You will bring your theoretical and practical expertise to establish and support mouse models, assay systems and deliver datasets that will have direct impact on the drug discovery process and pipeline.

Accountabilities: In this laboratory-based position within Oncology Research, you will develop, design, conduct and analyze both in vivo experiments to backss the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics. You will be expected to support cross-functional

teams and work collaboratively with project leaders to ensure the timely generation, and dissemination of critical program data, and contribute to scientific publication goals.

Essential Skills/Experience: B. S with 5-10, M. S or Ph. D. with 2-5 years research experience in Cancer biology, Immunology or other related scientific subject area. Biotechnology or medical industry experience preferred but not essential. Experience developing and working with complex in vivo models. Experience delivering in vivo pharmacology studies in mouse tumor models. Experience with a range of in vitro skills. Works independently, backsses, and reports data in a clear and concise manner. Maintains a well-developed

understanding of approaches to drug discovery. Ability to drive, manage, execute and deliver results for complex multi-functional projects.

Proven ability to manage, motivate, and develop direct reports. Strong interpersonal and collaboration skills. Excellent communication and presentation skills. A proven track record of high productivity and scientific publications in peer reviewed journals. Desirable Skills/Experience: Experience with xenograft and humanized models of cancer. Experience conducting in vivo research using biologics including, peptides, antibodies, antibody-drug conjugates, engagers and small molecules. Experience designing, conducting and analyzing high parameter flow cytometry immune-phenotyping studies.

Experience in drug development in medical or biotech industries. Experience in leading part of a project through key milestones with tight timelines. At Astra Zeneca's Oncology R&D department, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are united in our vision to eliminate cancer as a cause of death. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next.

We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world. About the Waltham Site Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park Bio Hub, just west of the city center. Our Bio Hub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas.

Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers. Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged.

This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community. We commit to those areas where we think we can really change the course of medicine and bring big new ideas to life. So, if you're curious about what science can do, then you're our kind of person. Join us and help make a difference in the world!

Please contact Bobbi Poole, our Talent Acquisition Partner. Closing Date: January 5, 2024 Competitive remuneration and benefits apply We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package. Where can I find out more- Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Astra Zeneca embraces diversity and equality of opportunity.

We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Please contact us to request accommodation. Date Posted 08-Dec-2023 Closing Date 04-Jan-2024Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be.

We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.