Scientist - Hybridoma Technology | Gaithersburg, MD

About Astra Zeneca At Astra Zeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe.

As a part of our Biologics Engineering team in Gaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. About Astra Zeneca in Gaithersburg, MD Our Gaithersburg, Maryland facility creates

life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US.

Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee

healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center.

This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. Summary of the Group The Biologics Engineering department at Astra Zeneca is constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're utilizing our expertise in protein and antibody engineering to enable novel therapeutic approaches to Oncology, Respiratory, Inflammatory, Cardiovascular and Infectious disease.

We offer a unique and strong collaborative network as part of the Astra Zeneca family, as together we explore new and exciting technologies. Main Duties and Responsibilities: The Biologics Engineering group is seeking a talented and highly motivated scientist to join our Hybridoma team. The successful candidate will have strong background in cell biology and will be conducting hybridoma campaigns to identify novel antibodies to different therapeutic targets. The applicant will operate independently and in collaboration with other team members and scientists across research to develop our next generation of drugs.

The selected individual will be well-organized and a productive bench scientist who can learn new procedures, design and execute experiments efficiently, as well as analyze, and interpret data. Strong team-based communication and presentation skills will be required. Design and execute experiments to generate therapeutic and reagent antibodies using the hybridoma platform Screen for potential hits using HTP platforms (ELISA/FACS)Small scale antibody expression and purification Interpret data in the context of multidisciplinary project teams Education & Experience Requirements : Master's Degree in Cell Biology, Immunology or other related fields with a minimum of 2+year or Bachelor's Degree with 5 years of relevant experience in industry (preferred) or academia and at least 1-year hands-on experience in hybridoma development.

Required Skills : Must have hands-on experience in hybridoma technology, including but not limited to designing experiments, immunogen preparation, animal immunization, cell culture, cell fusion and post-fusion screening. Experience performing high throughput screening methods( ELISA, Flow cytometry)Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset.

Ability to learn and embrace new technologies quickly, work independently, multi-task and manage shifting priorities Rigorous logical thinking, good communication skills and the ability to work within teams. Active work attitude, strong sense of responsibility. Maintain up-to-date knowledge of the latest advances in antibody discovery technologies, and contribute to the development of new and innovative approaches. Excellent organizational skills and data presentation. Maintain accurate and detailed laboratory notebooks, and ensure compliance with all relevant regulations and guidelines Desired Skills : Experience with NGS and 10XGenomics for antibody discovery using B-cell technologies Familiarity with automation and High-Throughput screening (e.

g. Hamilton, i Que3) Experience in small-scale antibody expression and purification is desirable Skilled in Flow cytometry Molecular biology experience a plus Date Posted 05-Dec-2023 Closing Date 30-Dec-2023Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.

We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.