Scientist, Early Oncology, Tumor Targeted Delivery | Gaithersburg, MD

We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life. Astra Zeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death.

A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers. We are seeking a highly motivated and independent Scientist with experience in cancer biology with a track record of scientific excellence in in-vitro cancer modeling, to join our antibody-drug conjugate (ADCs) Platform

team in Gaithersburg, MD USA. As a Scientist you will be a key member of a team focused on delivering all aspects of pharmacology support. You will bring your theoretical and practical expertise to establish assay systems and deliver datasets that will have direct impact on the drug discovery process and pipeline.

Accountabilities: Working in this laboratory-based position within the Early Oncology ADC Platform Development Team, you will develop, design, conduct and analyze in vitro experiments to assist in the development of our next generation ADC therapeutics. Specifically, you will help evaluate how changes to our antibodies, linkers and warheads can optimize the therapeutic index

of our ADCs. You will be expected to support cross-functional teams and work collaboratively with project managers to ensure the timely generation and dissemination of critical program data.

As a highly organized, self-motivated individual with a strong background in laboratory science you will stay up to date with relevant technical and intellectual scientific expertise in the ADC field, tumor biology and cancer modeling and have a genuine passion for this field of research. The candidate may also conduct ex vivo analyses of our ADCs based on interest and experience. Essential Skills/Experience: Bachelor's degree with >5 years of research experience in cancer/cell biology, or a Master's degree in cancer/cell biology.

Prior experience in the biomedical industry preferable. Experience with routine cell culture, particularly culture of tumor cells Experience backssing in vitro activity of therapeutic compounds via assays to determine binding and internalization (e. g. flow cytometry or ligand-binding assays), cytotoxicity (e. g. Cell Titer Glo assays), and mechanism of action (e. g. Western Blot analysis) Works independently with minimal supervision to conduct experiments Excellent communication and presentation skills to report data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery Strong interpersonal and collaboration skills together with evidence of delivery in a team-oriented, collaborative environment A proven track record of productivity; contributions to scientific publications in peer-reviewed journals preferred Desirable Skills/Experience: Experience in evaluation of ADCs Experience running combination screening assays Experience with high throughput screening (e.

g. use of equipment such as the ECHO acoustic liquid handler) Experience with flow cytometry and relevant analysis software (e.

g. Flow Jo) Knowledge of the industrial drug discovery process When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Why Astra Zeneca?

As Scientists in Oncology, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are a science-based, leading and decisive Oncology enterprise united in our vision to eliminate cancer as a cause of death. The pioneers, we make bold moves that transform the way cancer is treated and truly improve patient outcomes. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. Supportive teammates, we draw on diverse knowledge from across the business and external partners to come to bear on the toughest medical challenges.

Empowered by the business and each other, we embody courage and curiosity. Taking smart risks, challenging the norm and learning from failures. Be empowered to act fast on smart risks! Keep ahead in the fast-paced Oncology field. Be empowered at every level to prioritize and make bold moves. It powers us to be fearless decision-makers, who speak up and constructively challenge. Always following the scientific evidence to act on smart risks. About Our Gaithersburg Oncology Hub Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world.

This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more.

This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. So, what's next- Ready to make a difference? Apply today! Please contact Bobbi Poole, our Talent Acquisition Partner. Closing Date: December 29, 2023 Competitive remuneration and benefits apply We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive.

We have a generous paid time off program and a comprehensive benefits package. Where can I find out more- Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be.

We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.