In Vivo Scientist, Oncology Research | Waltham, MA

areas where we believe we can really change the course of medicine and bring big new ideas to life. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person. Astra Zeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death.

A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers. This Opportunity We are seeking a highly motivated and independent Scientist in cancer pharmacology

with a track record of scientific excellence in the area of in vivo cancer modeling, to join our In Vivo Pharmacology Team in Waltham, MA USA. As a Scientist you will be a key member of a team focused on delivering all aspects of in vivo pharmacology support.

You will bring your theoretical and practical expertise to establish assay systems and deliver datasets that will have direct impact on the drug discovery process and pipeline. Key Duties and Responsibilities Working in this laboratory-based position within Oncology Research you will develop, design, conduct and analyze in vivo experiments to backss the function of our candidate oncology drugs and dissect the mechanism of action

of novel cancer therapeutics. You will be expected to support cross-functional teams and work collaboratively with project leaders to ensure the timely generation and dissemination of critical program data, and contribute to scientific publication goals.

As a highly organized, self-motivated individual with a strong background in laboratory science you will stay up to date with relevant technical and intellectual scientific expertise in tumor biology, pharmacology and cancer modeling and have a genuine passion for this field of research. Essential Requirements B. S, in Biology, Pharmacology or other related scientific discipline with 3-6 yrs. relevant scientific experience; M.

S. - 2-5 yrs. MS desired but not required. Experience developing and working with complex in vivo models of cancer, such as cell line derived xenograft (solid and hematological tumors) patient derived xenograft (PDX), syngeneic and autochthonous mouse models. Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies. Experience with a range of in vitro skills, e. g. cell culture, molecular biology, immunoblotting, flow cytometry and ELISA. Works independently, backsses and reports data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.

Maintains a well-developed understanding of approaches to drug discovery and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed. Strong interpersonal and collaboration skills together with evidence of delivery in a team-oriented, collaborative environment. Excellent communication and presentation skills Desirable Requirements Biotechnology or medical industry experience preferred but not essential.

Experience with orthotopic xenograft and humanized models of cancer. Experience using biologics including, peptides, antibodies, or antibody-drug conjugates. Knowledge of the medical industry drug discovery process. About the Waltham Site Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park Bio Hub, just west of the city center. Our Bio Hub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science.

We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers. Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center.

This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility.

Join us in our unique and ambitious world. So, what's next- Are you already envisioning yourself joining our team? Good! We can't wait to hear from you! If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner. Closing Date: January 10, 2024 Competitive remuneration and benefits apply We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more? Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.

We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Date Posted 13-Dec-2023 Closing Date 09-Jan-2024Astra Zeneca embraces diversity and equality of opportunity.

We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.