Scientist - Bacteriology and Vaccine Discovery | Gaithersburg, MD

MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. The early Vaccines and Immune Therapies department at Astra Zeneca is developing new and innovative vaccines against bacterial pathogens.

We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel platforms to deliver vaccines against viral and bacterial pathogens. We're industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part

of the Astra Zeneca family, as together we explore synergies between small and large molecules. Astra Zeneca has a dynamic environment that fosters collaboration and innovation.

We attract top minds and we nurture and build top talents. What You'll Do Design, develop, and implement in vitro and in vivo experiments to characterize and validate novel targets against bacterial pathogens. Essential For the Role: A Master's degree with 4-6 years of experience or Bachelor's degree with 6-10 years of equivalent experience in assay development, bacteriology, cell biology, and in-vivo work. A successful candidate will be a well-grounded critical thinker who can design and implement in vitro (bacterial

biofilm and cell attachment assays, bacteria functional activity assays such as serum bactericidal, opsonophagocytic killing and anti-cytotoxic assays) and in vivo studies (mouse lung infection, bacteremia) and correlate these activities to backss the potential efficacy of monoclonal antibodies against bacterial pathogens.

Broad and strong experience with relevant cellular and antibody-based immunological techniques to characterize and select anti-bacterial monoclonal antibodies (e. g. FACS, western blot, ELISA, bacterial culture, bacteria cell-based ELISA, surface and intra-cellular target staining for cytofluorimetry) is required. In vitro based assays to quantify pro-inflammatory mediators in animals (ELISA, Luminex and MSD platforms, cell-based assays) Experience in animal procedure (intraperitoneal, intranasal, intravenous injections), bacterial disease models (lung infection, bacteremia) The candidate must be an effective oral and written communicator with a demonstrable track record of quality publications.

In addition, the individual must be dedicated to maintaining high laboratory standards, good record keeping, with high regard to quality and safety and must possess good organizational and interpersonal skills in a highly interactive multidisciplinary team oriented environment.

Desireable for the role: Experience in molecular biology (e. g. bacteria mutagenesis, DNA manipulation and cloning, sequence analysis, plasmid vector design and construction) would be a plus. Why Astra Zeneca? At Astra Zeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being bold - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-medical company can be.

This means we're opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey. So, what's next! Apply today! Are you ready to bring new insights and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours. To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel qualified for this opportunity.

If you know someone who would be a great fit, please share this posting with them. Where can I find out more? Check out our landing page for more information on our BPD group careers. /bpd Our Social Media, Follow Astra Zeneca on Linked In /company/1603/Follow Astra Zeneca on Facebook /astrazenecacareers/Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Date Posted 29-Sep-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.

We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. All qualified applicants will receive consideration for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status.

Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.