Senior Scientist Translational PKPD | Waltham, MA

We currently have an exciting opportunity for someone who has a passion for PKPD modeling and DMPK science, applied to Cancer biology, ideally with experience of working with large molecule drug projects to join our team. As a Senior Scientist Translational PKPD, you will have the opportunity to drive strategy and provide global leadership in PKPD science on Antibody drug conjugates and Radio immuno- conjugates.

Your day-to-day role is to provide projects with specialist modeling input into exploring the PK/PD/Efficacy in pre-clinical models, and using these models in order to iteratively build an understanding of the dose & schedule requirements for therapeutic intervention across different

patient populations as a single agent and combined with other agents. Accountabilities: Representing Translational PKPD group and providing overall scientific leadership for cross functional and external collaborations involving DMPK.

Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP). Predicting human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials. Driving learning through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing. Leading and participating

in Oncology strategic scientific initiatives and continuous improvement projects by providing expert M&S knowledge.

Having a breadth of influence and impact across Astra Zeneca Clinical Pharmacology and externally within their discipline. Identifying, championing and developing new insights. Leading scientific discipline networks and acting as a focus for debate within the Astra Zeneca scientific community. Advising on and participating in the development of Discovery or Development strategies in PKPD. Managing student and Post Doc programmes. Leading external collaborative projects with academic or cross-pharma pre-competitive groups. Providing disciplinary scientific leadership and presenting work through patents, publications and lectures.

Requirements: Education: Ph D, Completing Ph D before start date of position (preferably February 2024), Masters with at least 3 years of experience, or equivalent degree in a field with a significant component of Modeling & Simulation, such as systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, medical sciences or applied mathematics. 0-4 years of experience in a subject area with a significant component of Modeling & Simulation, such as systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, medical sciences or applied mathematics.

Desirable Experience: Relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting with a focus on ADC or RIC, or a MS degree with proven industry experience. Experience in a project-facing role within medical R&D. Comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development with a strong publication record. Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to prespecified quality and cost.

Specialist in tools such as Win Non Lin/Phoenix NLME, Non Mem, Berkeley Madonna, MATLAB, and Sim CYP. Excellent interpersonal and communication skills coupled with strong influence and leadership skills. Providing disciplinary scientific leadership and presenting work through patents, publications and lectures. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions.

That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. At Astra Zeneca, we follow the science to explore and innovate. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science.

Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. It's our combination of curiosity and courage that drives us, inspired by the possibility of doing things that have never been done before. Empowered to step up, we free ourselves from fear of failure to dig deep into the biology of complex diseases and make bold decisions. Celebrating our successes and failures along the way. Are you ready to embrace new and varied opportunities to develop and learn? Are you ready to be part of a team that makes a bigger impact on patients' lives?

If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be. Apply now! Date Posted 06-Dec-2023 Closing Date 05-Feb-2024Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e.

g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.