Lead Computational Chemist - Oncology R&D | Waltham, MA

Astra Zeneca is a global, science-led, patient-focused biomedical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading medical companies.

At AZ, we're proud to have an exceptional workplace culture that encourages innovation and collaboration. Here, employees are empowered to express different perspectives - and made to feel valued, energized and rewarded for their ideas and creativity. AZ is a place where passionate people can immerse themselves in their work and make significant contributions to scientific excellence and medicines - does this describe

a place where you would like to work? At Astra Zeneca, we turn ideas into life-changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.

We're passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life! Astra Zeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer and to ultimately eliminate cancer as a cause of death! What you'll do: We are seeking a computational

chemist for our Oncology medicinal chemistry department based in Waltham, Massachusetts.

The successful candidate will be a professional computational chemist, with a passion for drug discovery and ideally experience of working in drug discovery project teams within a biotech or medical setting. You will be working closely with an established, transnational team of computational chemists within Astra Zeneca working on oncology drug discovery projects across a range of modalities and will have access to innovative computational methods, such as our FEP and AI platforms, and excellent lead generation capabilities. Major Responsibilities: As a leading member of the medicinal chemistry design team, you will be responsible for: Setting and delivering on computational and medicinal chemistry strategies to impact project success at all stages from drug target identification through to clinical candidate nomination.

You will have accountability for setting the computational chemistry strategy, carrying out structure- and ligand-based design and data analysis, extracting insight from large proprietary structural biology and SAR data sets; your contributions to molecular design will be expected to result in inventorship on patent applications. You will work closely with scientists from other disciplines including structural biology, biophysics, ADME/DMPK and safety sciences as part of the wider drug discovery project team and will present your work regularly to peers and senior partners.

Depending on experience and interest, you might also function as the lead chemist for a drug discovery project. At Astra Zeneca, we value scientific innovation. Maintaining an awareness of the current state-of-the art, you will identify promising new computational methodologies or technologies that could benefit drug discovery and will develop and implement these through internal or external collaborations, sharing exemplary practice across Astra Zeneca.

You will be expected to publish your work regularly in high quality scientific journals and at national and international conferences. You'll have the opportunity to build academic collaborations and to supervise graduate scientists and postdocs, as well as to mentor colleagues. The scope for personal development is vast. Education, Qualifications, Skills and Experience: Requirements: Ph. D. degree in computational chemistry (or similar), ideally with greater than 5 years of experience working as a computational chemist on drug discovery projects in a medical or Biotech setting, or B.

Sc. /M. Sc with 10+ years of experience Broad experience in protein structure and dynamics, structure- and ligand-based design, data analysis and/or property prediction A passion for drug discovery and an excellent understanding of medicinal chemistry concepts Innovative problem-solver, with a track record of impacting drug project delivery Scientific and project impact exemplified by high quality scientific publications Strong oral and written communication skills, team-working and time-management skills Why Astra Zeneca?

At Astra Zeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-medical company can be. This means we're opening new ways to work, pioneering innovative methods and bringing unexpected teams together. Interested? Come and join our journey. Site Description: Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park Bio Hub, just west of the city center.

Our Bio Hub facility, is a bold new R&D initiative, which cultivates life science discoveries and the exchange of ideas. Here, we play host to some of the most ground breaking technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to crafting a culture of inclusion and collaboration.

With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers. Our Waltham site offers a variety of amenities to help book efficiency and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, & full-service cafeteria. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while growing collaboration between teams and the greater research community. So, what's next?

A place built on courage, curiosity, and collaboration - we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take calculated risks that write the next chapter for our pipeline. If you are swift to action, confident to lead, willing to collaborate, and passionate about the possibilities, then we are keen to hear from you! Where can I find out more? Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Next steps : Apply today, or connect with our Talent Acquisition Partner - Kayla Harris: /in/kayla-harris-8723ab13b/ for a confidential discussion to explore this opportunity further.

We are looking forward to hearing from you! Date Posted 13-Nov-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e.

g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.