Location: Boston
Company: Eli Lilly And Company
communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Akouos is building a leading gene therapy company focused on hearing disorders.
We are a precision genetic medicine company dedicated to developing gene therapies with the potential to restore, improve, and preserve high-acuity physiologic hearing for individuals living with disabling hearing loss worldwide. Restoring, improving, and preserving high-acuity hearing is an area of high unmet need in medicine: 466 million people worldwide have disabling hearing loss, and there are no FDA-approved
therapies to address its underlying causes. Akouos was founded in 2016 by leaders in the fields of neurotology, genetics, inner ear drug delivery, and AAV gene therapy.
Listening is in our DNA. We believe the only way to achieve our ambitious goals is to engage as one team, listen to each other, and trust in ourselves and our science. The Target Discovery and Genetic Technology and Innovation teams are seeking a motivated and committed scientist, with deep experience in molecular biology, to contribute to the evaluation and development of AAV vectors for the treatment of genetic and acquired forms of hearing loss. A successful candidate will work independently and perform benchwork that
supports discovery efforts and contributes to IND-enabling studies.
The scope of work includes the design, execution, and analysis of in vitro and ex vivo experiments using novel AAV vectors, with an emphasis on Next-Generation Sequencing (NGS) studies, and the implementation of organizational methods to support everyday lab operations. The successful candidate will be self-motivated and creative, with a desire to succeed in a highly collaborative and fast-paced environment. Job Responsibilities: Execute in vitro and ex vivo nonclinical experiments for the development of genetic medicines for the inner ear, including the following: Design and conduct in vitro , ex vivo , and in vivo single-nuclei RNA-seq experiments including sample processing, implementing 10X Genomics workflows, library generation and Illumina sequencing.
Design, conduct, and analyze in vitro transfection and transduction experiments using clonal cell lines and/or primary cell lines and performing such readouts as cell-based assays, luminescence readouts, epifluorescent microscopy, flow cytometry, q PCR, and/or western blot. Maintain accurate and timely documentation of activities through meticulous lab notebook practices and contributions to reports. Analyze, interpret, and present data for experiments, with the ability to clearly communicate results in written and oral formats for team feedback.
Organize key lab operations including leading and executing coordinated orders of specialized materials and instruments, and generation and maintenance of databases for samples and reagents. Basic Qualifications: Bachelor's Degree and/or Master's Degree in cellular biology, molecular biology, virology, medicine, or related field with 7+ years of relevant laboratory work experience; biotech or medical industry experience preferred but not required. Additional Skills/Preferences: Extensive experience in sample processing and execution of NGS studies for bulk and single-cell RNA-Seq, including sample preparation, 10X Genomics platform, library preparation, and sequencing.
Experience with RNA analyses (q PCR) and protein analyses (western blot). Experience with mouse handling, mouse tissue harvest, and tissue handling. Demonstrated ability to function as a member of an interdisciplinary team and contribute within a highly collaborative and fast-paced environment. Exceptionally organized and detail oriented. Excellent computer skills and Microsoft Products proficiency (Outlook, Excel, Word, Power Point, etc.
) to support database tracking of key lab operations, including samples, and protocols. Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively " Lilly" ) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( xyz X@lists. ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process.
Any other correspondence will not receive a response. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, interactionual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women's Network, Working and Living with Disabilities.
Learn more about all of our groups. #We Are Lilly
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