Senior Scientist, Immunology Discovery | San Diego, CA

leaders in the field of immunology having developed the anti-TL1A monoclonal antibody MK-7240 (formerly PRA023) and continue to lead with new indications and modalities targeting the TL1A pathway. The department of Immunology Discovery and Translational Sciences (IDTS) leads and supports our company's pipeline programs encompassing early target discovery and validation, drug discovery, translational sciences, and precision medicine in collaboration with multi-disciplinary teams at our company, including bioinformatics, immunology discovery and chemical biology, antibody discovery, and clinical development.

IDTS is currently seeking a highly motivated, detail-oriented Sr. Scientist with

a passion for improving patient lives to support internal discovery efforts at our Research Division's San Diego. The Sr. Scientist will work in a matrixed environment with a focus on immune targets and leveraging genetics to stratify patients for drug treatment.

Main job duties include, but are not limited to: Working with team leaders to develop strategy and drive drug discovery, translational medicine, and precision medicine / diagnostics (Dx) discovery programs forward Representing IDTS in working groups and/or project teams Collaborating with bioinformatics team members to generate datasets supporting translational medicine and Dx discovery Developing and running cell-based assays

to characterize drug target pathway activity in primary cells derived from patient samples Using immunoassay-based methods to determine cytokine and target levels in biological samples Analyzing data and communicate findings to team members Education Minimum Requirements: Ph D in immunology, cell biology, or related biomedical science and zero (0+) relevant academia and/or industry experience MS in immunology, cell biology, or related biomedical science with five (5) years relevant academia and/or industry experience BS in immunology, cell biology, or related biomedical science with seven (7) years relevant academia and/or industry experience Required Experience and Skills: Understanding of immune diseases, including current research and drugs in development Strong cell culture skills including developing cell-based functional assays in primary cells (e.

g. PBMCs) Proficiency in data analysis using Excel and Prism (Graph Pad) Experience with immunoassay platforms (e. g. ELISA, multiplex of our company) Experience in multi-color flow cytometry Ability to follow procedures and document experiments Strong communication and interpersonal skills with an eagerness to work with and support colleagues across the organization in a matrixed environment Preferred Experience and Skills: Understanding of the drug discovery process with industry experience Experience in developing and running transcriptomics experiments (bulk and single cell RNAseq) Background in biomarker discovery and development Understanding of principles of bioinformatics Background in genetics of immune disease and molecular diagnostics #Eligiblefor ERP Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders).

Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated.

Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission. Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, interaction, interactionual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U. S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement Pay Transparency Nondiscrimination We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together.

The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts U. S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U. S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.

This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely.

Please note, this Hybrid work model guidance also does not apply to roles that have been designated as " remote"Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected salary range: $107,600.00 - $169,400.00Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here. Search Firm Representatives Please Read Carefully Merck & Co. Inc. Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.

No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic VISA Sponsorship: Yes Travel Requirements: 10% Flexible Work Arrangements: On-Site Shift: 1st - Day Valid Driving License: No Hazardous Material(s): N/A Requisition ID: R272504PDN-9ad9c9c2-1e14-4563-b378-4b53b92b13e0