Scientist, Screening, Triage and Early Chemistry (ST&EC) | Escondido, CA

& Johnson, and you can count on us to keep working tirelessly to make that future a reality for patients everywhere, by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular & Metabolism, Immunology, Infectious Diseases & Vaccines, Neuroscience, Oncology, and Pulmonary Arterial Hypertension.

Visit us: The Global Discovery Chemistry group is committed to the delivery of high-quality drug candidates working with all five Johnson & Johnson Innovative Medicine Therapeutic Areas (TAs). This mission requires deep scientific expertise in a number of fields including

chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external partners.

Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as Scientist, Discovery Chemistry. We are seeking a chemist with excellent organic synthesis expertise to work in the Screening, Triage and Early Chemistry (ST&EC) group. In this laboratory-based position, the successful candidate will work with an interdisciplinary group to develop a lead finding plan, interpret screening data, triage screening hits and carry out hit expansion to identify validated lead series.

The candidate will partner with both internal and external medicinal chemistry teams to generate innovative solutions to synthetic and medicinal chemistry challenges within the context of small molecule drug discovery projects.

They will maintain close interactions with computer-assisted design scientists, biologists, pharmacologists, and medical development scientists. Strong communication skills and the ability to thrive in a team and results oriented environment are key attributes. This individual must also excel in communication and have strong interpersonal skills necessary to influence in a collaborative multidisciplinary environment. Key Responsibilities: Maintain a high level of efficiency in the laboratory setting.

Collaboratively support the advancement of compounds through high-throughput screening triage and hit expansion. Independently design and synthesize drug-like molecules applying medicinal chemistry knowledge and an understanding of ADME, pharmacokinetics, optimal physicochemical properties, and AI/ML predictive tools. Develop and implement clear synthetic strategies towards complex molecules using innovative synthetic methodologies. Collaborate with structure-based design groups to impact rational design of molecules.

Generate novel, testable hypotheses to enable clear decision making. Contribute to defining scientific strategies and goals within a project team setting. Present data and reports on project status at individual, group, and departmental meetings. Draft, complete and serve as lead author on research published in peer reviewed journals, and present work at scientific conferences. Education: Minimum of a B. S. /B. A. with a minimum of 2-4 years of experience or a MS degree with 1-3 years of experience is required. Experience and Skills: Postdoctoral experience or equivalent experience is preferred.

Consistent track record of achievement in the synthesis of complex molecules and/or synthetic methodology development, with deep knowledge of modern synthetic & analytical techniques is required. Proven track record of scientific contributions including peer reviewed publications, patents and presentations is required. Experience with computational chemistry methods and biophysical techniques such as X-ray crystallography is preferred. Independent thinking and the ability to effectively collaborate in a highly matrixed environment. is required. Excellent oral and written communication skills, including preparation of presentations is required.

The anticipated base pay range for this position is $102,000 to $163,300 Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www. careers..