Principal Scientist, m RNA Vaccines & Technology | Alabaster, AL

lipid nanoparticle drug products and participate in the development of next-generation RNA vaccine prototypes. ROLE RESPONSIBILITIES Lead the multi-step design, planning and execution of experiments to characterize the RNAs and their formulations for in vitro studies Develop, establish, and execute novel technology platforms (multi-cellular engineered culture systems, 3D bioprinting platform, high throughput live imaging system) to monitor vaccine-mediated immune responses, including T cell, Treg, NK cell or PBMC based immunotherapy assays Partner with director to contribute to scientific discussions and strategic internal/external collaborations aimed at advancing the RNA Platform Mentor junior

scientists' research activities and provide technical guidance when necessary BASIC QUALIFICATIONS Strong foundation in drug discovery process accumulated in prophylactic and therapeutic vaccine development Comprehensive knowledge and hands on experience with ex vivo cell-based assays to monitor vaccine-mediated T cell immunogenicity Hands on experience with cell culture (primary immune cells and established cell lines) and the utilization of cell-based assays to characterize RNA-based products (e.

g. Multicolor flow cytometry, ELISA/MSD/ELLA, Taqman RT-q PCR, Luminescence, and single cell RNAseq) Strategic agility, strong critical and logical thinking with ability to analyze problems

Contribute creatively to seed innovation projects through literature review and shape execution tactics.

Recommend changes to project direction based on an understanding of current literature and in-house experimental data. Excellent interpersonal, organizational, and collaborative skills, attentive to detail, and the ability to work independently and effectively in a highly dynamic cross-functional matrix and fast-paced environment Ph D in biology, biochemistry, immunology, molecular cell biology or a related field 3+ years relevant industry experience in pre-clinical research and in vaccine technical development PREFERRED QUALIFICATIONS Experience in establishing in vivo/ex vivo models for vaccine development RNA secondary structure and RNA folding characterization and m RNA stability analysis Analysis of m RNA translation through polysome profiling and/or ribosome profiling Data analysis of NGS-based technologies (RNA-seq, Ch IP-seq, sc RNA-Seq, Long-Read sequencing, etc.

) are preferred Experience with managing a small team PHYSICAL/MENTAL REQUIREMENTS Strong abilities in scientific analysis, cross-functional collaboration, people management, scientific writing, and public speaking required NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS On-site (laboratory-based).

Must be able to access or utilize reliable transportation to the Pearl River site Experimental designs may occasionally necessitate being on-site early/late or on weekends as needed Potential to work with/come in contact with infectious materials Work Location Assignment: On Premise The annual base salary for this position ranges from $96,900.00 to $161,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program.

We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U. S. Benefits (uscandidates. ). Pfizer compensation structures and benefit packages are aligned based on the location of hire.

The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure.

Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, interaction, interactionual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Research and Development