Location: Memphis
Company: St. Jude Children's Research Hospital
creative, and fun group of scientists at St. Jude Children's Research Hospital. Our research program centers on: development of state-of-the-art genomic methods for understanding the global activities of genome editors, protein engineering to improve their capabilities for precise editing, and translation to autologous genome edited hematopoietic stem cell therapies.
About the job opportunity. We are seeking an outstanding and highly motivated Scientist or Lead Researcher to help lead efforts to develop personalized genome editing treatments for bone marrow failure disorders. We care deeply about the success of our scientists and this job is a unique opportunity to learn about genomics,
genome editing, and protein engineering while contributing to the development of future individualized genomic medicines at St. Jude, with room for career growth and advancement.
Dr. Tsai is co-leading a new Blue Sky Project called PARADIGM (Partnership to Advance Development of Individualized Genomic Medicines) with goal of developing personalized genome editing therapies for St. Jude patients. You would have opportunities to lead exciting projects that include: Protein engineering of improved novel CRISPR base and prime genome editors with human cell-based directed evolution. Understanding the structure-function relationship of mutations identified from high-throughput screens on the
activity of genome editors. Perform deep mutational scanning of CRISPR-Cas orthologues and effector domains important for precise genome editing such as deaminases and reverse transcriptases.
Define the outcome of engineered variants on genome editing repair outcomes using high-throughput genomic methods. Help develop laboratory automation workflows to perform scalable protein engineering. You would learn valuable laboratory skills that include: Genome engineering, high-throughput genomics, next-generation sequencing, protein engineering, structural biology, liquid handling automation, hematopoietic stem cell cell culture and transfection, and data science.
Project-dependent responsibilities could include: Engineer CRISPR base and prime editors with improved activity and specificities. Test new strategies to edit human hematopoietic stem cells for treatment of bone marrow failure disorders, focused on rapid development of editing strategies for rare patient-specific mutations. Optimize lead protein candidates by structure-guided design and high-throughput screening. Apply new machine learning techniques to guide protein engineering design. Analyze experimental outcomes and develop high-quality summaries towards manuscripts and grant applications.
Draft manuscripts and figures for publication in high-impact journals. Minimum Education and/or Training for the position include: A B. S. in a relevant field, such as genomics, molecular and cell biology, 1 year or more of hands-on, research laboratory experience. Excellent communication, organizational, and presentation skills. Scientist Minimum Experience: Seven (7) years of relevant post-degree work experience is required Five (5) years of relevant post-degree work experience is required with a Master's degree Three (3) years of relevant post-degree work experience is required with a Ph D Lead Researcher Minimum Experience: Five (5) years of relevant, post-degree work experience is required Two (2) years of relevant post-degree work experience is required with a Master's degree No experience is required with a PHD St.
Jude Benefits St. Jude Children's Research Hospital is one of the world's leading pediatric hospitals whose mission is to advances cures for catastrophic childhood diseases. Consistent with the vision of our founder, no child is denied treatment based on race, religion, or ability to pay. St. Jude has been consistently named one of the best companies to work for by Fortune, Glass Door, and others.
St. Jude offers excellent benefits, great salary, help with relocation, and actively fosters professional development. As part of your role, you will have opportunities to attend and present at national and internatl provides employees with high-quality benefits choices. We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents. View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St.
Jude. Diversity, Equity and Inclusion: St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment.
As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. Have More in Memphis: Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis.
From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can " Have More in Memphis. " Other Information St. Jude is an Equal Opportunity Employer No Search Firms St.
Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
recognized one of the Best Places to Work by Glassdoor and People magazine's 50 Companies That Care. Our mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. We look for the best people to join our teams and provide world-class facilities, state-of-the-art technologies, and extraordinary support to ensure scientific progress to support our mission.
The Center for Modeling Pediatric Diseases (CMPD) plays a key role in providing that support. As a new initiative at St Jude Children's Research Hospital (SJCRH), its mission is to serve the research community by delivering high quality, fully characterized, patient-derived,
pluripotent cells. Our aim is to generate these cells on our fully automated, state of the art, robotic system. Our methodologies are based on the Nobel Prize winning work of Shinya Yamanaka, which culminated in the ability to create induced pluripotent stem cells (i PSCs) from terminally differentiated human somatic cells.
These i PSCs permit the derivation of both normal and disease phenotype, patient-matched cell lines, and are therefore key to developing personalized medicine approaches. i PSCs provide a vital tool to study the cellular and molecular mechanisms involved in patient-specific responses to treatments, and in the future will form the basis of creating patient-derived,
patient-matched cellular therapeutics. Since i PSCs are derived from somatic cells, they can be created without harvesting vital stem cell pools in the body.
For example, CMPD is able to generate i PSCs from blood and urine, which are collected as part of routine clinical monitoring. We therefore circumvent the ethical issues encountered by working with stem cells from donated oocytes, or embryonic stem cells. As CMPD establishes our methodologies and implements our automation we seek an exceptional and motivated individual who will be able to execute standard operating procedures accurately and efficiently. The transition from manual to automated requires a highly organized, methodical, and algorithmic mindset.
This role provides an exceptional opportunity to learn both manual and automation programming routines. Ability to demonstrate attention to detail is key, as is a desire to work in a highly reproducible manner, by close adherence to optimized SOPs. However, an ability to innovate, and determine where evolutions can be made to improve time and cost efficiencies, in coordination with the team, is also highly desirable. Daily implementation of advanced cell culture techniques, including differentiation protocols in the future, and the ability to undertake sophisticated characterization assays is required.
There are opportunities to learn bioinformatics and data analysis skills, including running machine learning pipelines to evaluate microscope images of developing i PSC colonies. Our automation system includes the latest model instruments: Hamilton Vantage; Hamilton Lab Elite; Cytation 5; Cytomat (500 capacity); King Fisher Flex; Bio Store III. If you are excited by using state-of-the-art instrumentation, if you are able to take a one-off research experiment and optimize it to make it unbreakably reproducible, and would like to do for biology what Henry T Ford did for car manufacturing, then we would like to hear from you!
Job Responsibilities The successful candidate will assist the CMPD Director to develop: Daily implementation of advanced cell culture techniques, including reprogramming / biobanking protocols, and the ability to undertake sophisticated characterization assays. Follows SOPs necessary to automate various manual stem cell workflows such as splitting of stem cells, the purification of specific populations, freezing cells, setting up and analyzing various quality control and characterization assays. Assists with the cryopreservation of bar-coded samples using an automated liquid N2 system.
Manages specific, but limited, laboratory functions such as inventory management, ordering, instrument maintenance etc. Demonstrates effort to increase knowledge in relevant areas of research and participates in the presentation and publication of research results, if necessary. Conducts scientific projects and maintains efficient laboratory operations with minimal supervision. Data entry into various databases Assists with stem cell training. Performs other duties as assigned or directed in order to meet the goals and objectives of the CMPD Core and of St Jude Children's Research Hospital.
Minimum Education Bachelor's degree in an appropriate scientific field is required. Researcher Minimum Experience: no experience required. Sr. Researcher Minimum Experience: Two (2) years of relevant, post-degree work experience is required. No experience is required with a Master's degree. If interested, please contact: Sunita D'Souza, Ph. D. Dir-Center for Modeling Pediatric Diseases671 Galloway Avenue, ZY Building Room 1033Memphis TN, 38105Phone: 901 595 xyz XEmail : Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion.
Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St.
Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St.
Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
the opportunity to enhance their research skills and interests in a diverse, multidisciplinary group at the nexus of chemistry and biology. Accordingly, the opportunity exists for candidates to immerse themselves in world-class collaborations with leading experts in the fields of oncology, neuroscience, and infectious disease.
In addition, postdocs have access to a wealth of cutting-edge research core support services. Taken together, a St. Jude postdoc opportunity is an unbounded educational experience for trainees. The principal focus of the Neumann lab at St. Jude Children's Research Hospital is developing novel radiomedicals with diagnostic and/or therapeutic potential toward improving
disease outcomes. We often develop radiomedicals with the goal of translating them into imaging agents for Positron Emission Tomography (PET) to better delineate disease and biological status.
Our lab utilizes synthetic organic chemistry and radiochemistry to synthesize these novel molecules and imaging agents. We then characterize their associated biological activity in relevant cell culture and live animal imaging studies with the goal of clinical translation. We frequently use PET/CT and PET/MRI to evaluate our novel imaging agents in live animals. However, we are now also utilizing Focused Ultrasound techniques to improve therapeutic delivery to the Central Nervous System by reversible
blood brain barrier disruption and sonodynamic therapy. Postdoctoral fellows at St.
Jude are entitled to incredible benefits including a 24% increase in salary compared to the standard PGY scale, sign-on bonus, a substantial annual allowance for professional development, a laptop computer, paid leave, relocation stipend and assistance, and a generous array of benefits including health, dental and vision coverage, and a retirement savings program. Other Information St. Jude is an Equal Opportunity Employer To apply, please send your CV to the email address provided and include the job title in the email subject line. No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities.
Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
barriers. That's why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.
Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. Job Responsibilities: Tracking the inventory of chemical compounds, maintaining accurate records, and ensuring the availability of compounds when needed. Managing the storage of compounds in St. Jude's internal repository, which may include researching and maintaining appropriate storage conditions (e. g.
temperature, humidity) and retrieving samples for CBT collaborators as requested. Preparing compounds for distribution to researchers, including dilution, aliquoting, or other sample handling procedures.
Reformatting new compound libraries, purchased or synthesized in-house. This includes the generation of assay-ready plates. Distributing samples to researchers while keeping track of the quantities sent and maintaining proper documentation. Recording and managing data related to compounds, including compound information, storage conditions, and usage records. Having a basic knowledge of analytical techniques used to characterize compounds and verify their identity and purity. Maintaining
up-to-date knowledge of industry techniques, hardware, labware, and software.
Utilizing compound management software to maintain an organized and searchable database of compounds in collaboration with the CBT Lead Discovery Informatics Center, including the internal request system in Share Point. Collaborating with scientists and researchers to understand their specific compound needs and developing protocols to ensure they receive the appropriate samples. Performing experiments to ensure that compounds are stored, handled, and distributed in compliance with safety regulations and best practices. Addressing issues related to compound degradation, contamination, or any discrepancies in compound records by performing experiments.
Collaborating with the CBT Compound Collection team, contributing to designing and organizing compound libraries for high-throughput screening or other applications. Using automation and robotic systems to improve compound management efficiency and accuracy. Reformat new libraries. Training lab personnel on compound management inventory, formatting, and delivery. Minimum Education: Bachelor's degree in relevant scientific area is required. Minimum Experience: Two (2) years of relevant, post-degree work experience is required with a Bachelor's degree.
No experience is required with a Master's degree. Benefits Your health and well-being are important to us. That's why St. Jude Children's Research Hospital provides employees with high-quality benefits choices. We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents. View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St.
Jude. Diversity, Equity and Inclusion St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment.
As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. Have More in Memphis Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis.
From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can " Have More in Memphis. " Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities.
Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
platforms. Candidates with bioinformatic workflow experience are preferred. Although projects are loosely defined within the scope of the NIH R01 award, there are opportunities for new mutually agreed upon directions. Trainees will interact with a multidisciplinary team of translational and clinical scientists with multiple opportunities to present their work and develop their scientific and soft skills.
The lab includes Ph. D. -level staff, postdoctoral fellows, and graduate students. Trainees from the Leggas lab have transitioned to academic, industry, or government positions. Other Information St. Jude is an Equal Opportunity Employer To apply, please send your CV to the email address
provided and include the job title in the email subject line. No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities.
Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
